Another Lesson From the Factor V Leiden Mouse
نویسندگان
چکیده
منابع مشابه
Another lesson from the factor V Leiden mouse: thrombin generation drives arterial disease.
The discovery of activated protein C (APC) resistance by Dahlbäck in 19931 was a milestone in thrombophilia research that led to major advances in our understanding of the biochemistry, genetics, and clinical manifestations of hypercoagulability. APC resistance was quickly demonstrated to be caused by a single point mutation (1691G3A) in the coding region of the factor V gene.2 This mutation, f...
متن کاملFactor V Leiden and Inflammation
Factor V Leiden, is a variant of human factor V (FV), also known as proaccelerin, which leads to a hypercoagulable state. Along these years, factor V Leiden (FVL) has been studied from the pathophysiologic point of view, and research has been focused on finding clinical approaches for the management of the FVL associated to a trombophilic state. Less attention has been paid about the possible r...
متن کاملEvolution of Factor V Leiden.
Factor V Leiden is a procoagulant mutation associated with venous and arterial thrombosis and pregnancy complications. Its high prevalence of 5% in Caucasians suggests that there are evolutionary benefits as well. Carriers are indeed reported to have various advantageous phenotypes related to haemostasis, inflammation and fertility: less acute blood loss; less menstrual blood loss; decreased ri...
متن کاملMechanisms of the factor V Leiden paradox.
OBJECTIVE Carriers of the factor V Leiden mutation (FVL-carriers) have a substantially increased risk of deep venous thrombosis (DVT), whereas the risk of pulmonary embolism (PE) is only mildly increased compared with noncarriers. So far few studies have investigated possible mechanisms for this so-called FVL paradox. METHODS AND RESULTS Consecutive patients with a first DVT or PE were includ...
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Knowingwhen awound can safely be closed is an iconic problem for surgery. When an extremity wound is closed too soon, with resulting infection requiring further debridement, an amputation can result. Or a minor amputation can be converted into a major amputation. Patient welfare is on the line, and expenses are considerable in these situations. The novel work (Forsberg et al. 2015), published i...
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000162489.34887.fa